Sticks and stones

While contemplating bad names to call someone, it occurs to me that most names "sonofabitch" and "bastard" are names which really don't reflect on the person called that name, but do reflect on his mother. A "bitch" and the "c" word both refer to women. If you want to call a man the worst thing, what would it be? One suggestion is "a-hole", but couldn't that be non-gender-specific? I did come up with the traditional southern epithet "sorry" - as in "He's just sorry" meaning lame, useless and unredeemably bad.